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Magnetic resonance imaging in subacute necrotizing encephalomyelopathy (Leigh's disease)
Author(s) -
Koch Thomas K.,
Yee Melvin H. C.,
Hutchinson Harrol T.,
Berg Bruce O.
Publication year - 1986
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410190617
Subject(s) - magnetic resonance imaging , medicine , basal ganglia , leigh disease , lesion , radiology , brainstem , neuroimaging , radiography , pathology , central nervous system , biochemistry , psychiatry , gene , mitochondrial dna , endocrinology , chemistry
Abstract Magnetic resonance imaging (MRI) offers a sensitive alternative to computed tomography (CT) for lesion localization. Patients with subacute necrotizing encephalomyelopathy (SNE) may be diagnosed by finding focal lesions on CT that correspond to sites of anatomical involvement. We report serial CT and MRI scanning findings in a patient with clinical, radiographic, and laboratory evidence of SNE. MRI was more sensitive in detecting lesions involving the basal ganglia, brainstem, and cortex. We believe MRI is a valuable and sensitive means to establish an antemortem diagnosis of SNE.