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Edrophonium: An aid in the diagnosis of acute organophosphate poisoning
Author(s) -
Maselli Ricardo,
Jacobsen John H.,
Spire JeanPaul
Publication year - 1986
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410190517
Subject(s) - edrophonium , anesthesia , medicine , organophosphate , stimulation , paralysis , organophosphate poisoning , stimulus (psychology) , repetitive nerve stimulation , electromyography , surgery , physical medicine and rehabilitation , psychology , neostigmine , pesticide , agronomy , psychotherapist , biology
Unsuspected accidental cutaneous exposure to an organophosphate insecticide caused flaccid paralysis in a 10‐year‐old girl. Electromyogram demonstrated repetitive compound muscle action potentials in response to a single stimulus of nerve; decremental response, more prominent at higher rates of stimulation; worsening of decremental response after edrophonium injection; and normal nerve conduction velocities. Electromyogram with repetitive nerve stimulation and an edrophonium test may provide a simple and rapid method for diagnosis of acute organophosphate poisoning.