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Successful treatment with tocainide of recessive generalized congenital myotonia
Author(s) -
Streib Erich W.
Publication year - 1986
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410190515
Subject(s) - myotonia , medicine , irritability , acetazolamide , myotonia congenita , anesthesia , verapamil , channelopathy , pediatrics , myotonic dystrophy , menopause , calcium
A patient with recessive generalized congenital myotonia and severe, disabling weakness underwent various forms of treatment while being monitored electrophysiologically. Phenytoin, verapamil, and acetazolamide were ineffective, but tocainide yielded good results. Improvement was dose‐dependent, and was limited by irritability and action tremor when the patient was taking 1,600 mg per day.