Premium
The human anti–myelin‐associated glycoprotein IgM system
Author(s) -
Murray Norman,
Page Nicole,
Steck Andreas J.
Publication year - 1986
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410190508
Subject(s) - paraproteins , idiotype , antibody , glycoprotein , monoclonal antibody , myelin , immunology , myelin associated glycoprotein , antigen , immune system , immunoglobulin idiotypes , monoclonal , chemistry , biology , microbiology and biotechnology , central nervous system , neuroscience
Two mouse monoclonal antiidiotypic antibodies that react with human monoclonal IgM antibodies with specificity for myelin‐associated glycoprotein (MAG) have been used to study the immunological specificity of the reported cross‐reactions involving the anti‐MAG IgM. Both of the antiidiotypic antibodies are shown to react with the combining site of their respective idiotypic IgM and to inhibit the reaction between IgM and MAG. Using these antiidiotypic antibodies as “surrogate” antigen, we have demonstrated immune cross‐reactivity between MAG, a human peripheral nerve glycolipid, and a low‐molecular‐weight protein of human peripheral nerve myelin. In addition, we have used the two antiidiotypic antibodies to conduct a search for evidence of shared idiotypy among 34 different neuropathy‐associated paraproteins. Our results provide no evidence for a neuropathy‐associated idiotype, suggesting a degree of polymorphism in the human anti‐MAG IgM system.