Intrathecal interferon in subacute sclerosing panencephalitis | Zendy

Huttenlocher Peter R. | Zendy; Picchietti Daniel L. | Zendy; Roos Raymond P. | Zendy; Cashman Neil R. | Zendy; Horowitz Bernard | Zendy; Horowitz Marilyn S. | Zendy

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Intrathecal interferon in subacute sclerosing panencephalitis

Author(s) -

Huttenlocher Peter R.,

Picchietti Daniel L.,

Roos Raymond P.,

Cashman Neil R.,

Horowitz Bernard,

Horowitz Marilyn S.

Publication year - 1986

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.410190317

Subject(s) - subacute sclerosing panencephalitis , medicine , cerebrospinal fluid , intrathecal , lumbar puncture , hemiparesis , interferon , gastroenterology , pathology , immunology , anesthesia , measles , lesion , vaccination , measles virus

Five patients with clinically advanced subacute sclerosing panencephalitis (SSPE) were given human leukocyte interferon (IFN) by the lumbar route, 1 million IU every other day for a total of 30 days. Intrathecal IFN produced a meningeal inflammatory reaction in all patients and was associated with transient hemiparesis in 1. It persisted in the cerebrospinal fluid at measurable levels for 48 hours after a single injection. Although improvement was temporally related to intrathecal IFN in 1 patient, it is not clear whether this was induced by IFN or a spontaneous remission. A randomized controlled trial would be necessary to evaluate IFN critically as a therapy for SSPE.

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