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Suppressor T cells in myasthenia gravis and antibodies to acetylcholine receptor
Author(s) -
Lisak Robert P.,
Laramore Cynthia,
Levinson Arnold I.,
Zweiman Burton,
Moskovitz Anne R.
Publication year - 1986
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410190119
Subject(s) - myasthenia gravis , acetylcholine receptor , pokeweed mitogen , peripheral blood mononuclear cell , antibody , acetylcholine , immunology , population , suppressor , receptor , medicine , endocrinology , biology , in vitro , biochemistry , environmental health , cancer
We cultured blood mononuclear cells of patients with myasthenia gravis both with and without removal of T8 suppressor cells. The levels of synthesized antibodies to acetylcholine receptor and IgG as well as the frequency of immunoglobulin‐secreting cells were all higher in pokeweed mitogen–stimulated cultures depleted of T8 + cells. Thus, autologous suppressor cells within the T8 + population exert some regulatory control over anti‐acetylcholine receptor–producing cells in patients with myasthenia gravis.