Premium
Age differences in intercorrelations between regional cerebral metabolic rates for glucose
Author(s) -
Horwitz Barry,
Duara Ranjan,
Rapoport Stanley I.
Publication year - 1986
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410190111
Subject(s) - positron emission tomography , frontal lobe , parietal lobe , fluorodeoxyglucose , temporal lobe , carbohydrate metabolism , medicine , psychology , endocrinology , nuclear medicine , neuroscience , epilepsy
Patterns of cerebral metabolic intercorrelations were compared in the resting state in 15 healthy young men (ages 20 to 32 years) and 15 healthy elderly men (ages 64 to 83 years). Controlling for whole‐brain glucose metabolism, partial correlation coefficients were determined between pairs of regional cerebral metabolic rates for glucose determined by positron emission tomography using [ 18 F]fluorodeoxyglucose and obtained in 59 brain regions. Compared with the young men, the elderly men had fewer statistically significant correlations, with the most notable reductions observed between the parietal lobe regions, and between the parietal and frontal lobe regions. These results suggest that cerebral functional interactions are reduced in healthy elderly men.