Premium
Conduction failure and nerve conduction slowing in experimental allergic neuritis induced by P 2 ‐specific T‐cell lines
Author(s) -
Heininger Kurt,
Stoll Guido,
Linington Christopher,
Toyka Klaus V.,
Wekerle Hartmut
Publication year - 1986
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410190109
Subject(s) - neuritis , fulminant , medicine , electrophysiology , adoptive cell transfer , pathology , anesthesia , t cell , immunology , surgery , immune system
P 2 ‐specific T cells (LiP 2 /A) mediate experimental allergic neuritis (EAN) in the Lewis rat after adoptive transfer to naive recipients. After a latent period of 4 days, injection of 2 × 10 6 line cells induced fulminant paraplegia and complete conduction failure in the peripheral nerves and roots, resembling acute axonal breakdown. Injection with 10 6 cells caused milder clinical signs, nerve conduction failure, and conduction slowing. Clinical and electrophysiological recovery from adoptively transferred EAN was nearly complete and its time course was inversely correlated to the initial severity of EAN. These findings suggest that EAN induced by the P 2 ‐specific T‐cell line can lead to a profound and rapidly evolving nerve dysfunction in a dose‐dependent fashion.