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Multiple sclerosis: Activated cells in cerebrospinal fluid in acute exacerbations
Author(s) -
Noronha Avertano,
Richman David P.,
Arnason Barry G. W.
Publication year - 1985
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410180617
Subject(s) - cerebrospinal fluid , multiple sclerosis , flow cytometry , phenotype , medicine , cell , immunology , antigen , pathology , chemistry , gene , biochemistry
Cerebrospinal fluid (CSF) lymphocytes from three young patients undergoing acute exacerbations of multiple sclerosis were studied by flow cytometry. Using a new method that simultaneously measures cell‐surface antigens and the cell‐cycle phase, we determined that the CSF lymphocytes in these patients were activated. The majority of the activated cells expressed the OKT4 phenotype, while very few expressed the OKT8 phenotype.