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Thyrotropin‐releasing hormone enhances motor neuron–evoked contractions of cultured human muscle
Author(s) -
Askanas Valerie,
Engel W. King,
Kobayashi Takayoshi
Publication year - 1985
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410180615
Subject(s) - motor neuron , thyrotropin releasing hormone , hormone , neuroscience , medicine , endocrinology , neuron , biology , disease
Thyrotropin‐releasing hormone (TRH), 1 to 2.7 mM, introduced to the medium of monolayer‐cultured human muscle innervated by cocultured fetal rat spinal cord with dorsal root ganglia, increased muscle fiber contractions 4.9 times ( p < 0.005). Doses higher than 5 mM, after increasing contractions for a few seconds, caused complete inhibition of contraction (autorefractoriness). Neither aneurally cultured human muscle nor innervated cultured human muscle blocked by 1 mM d ‐tubocurarine was excited by TRH. Thus, in this system TRH appeared to excite muscle contractions through direct or indirect action on motor neurons.