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Acute effects of antidepressants on hippocampal seizures
Author(s) -
Clifford David B.,
Rutherford James L.,
Hicks Frederick G.,
Zorumski Charles F.
Publication year - 1985
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410180611
Subject(s) - trazodone , maprotiline , bupropion , amitriptyline , desipramine , imipramine , antidepressant , medicine , kindling , anesthesia , phenobarbital , seizure threshold , anticonvulsant , convulsion , carbamazepine , epilepsy , pharmacology , psychology , hippocampus , psychiatry , alternative medicine , pathology , smoking cessation
Electrically kindled hippocampal seizures in rats were used to evaluate the acute effects of the antidepressants amitriptyline, imipramine, desipramine, bupropion, maprotiline, and trazodone on behavioral and electrical convulsions. All of the drugs reduced afterdischarge duration significantly. Behavioral seizures were not significantly reduced by bupropion or trazodone, whereas the other drugs did reduce seizure severity. Afterdischarge threshold was not modified by these drugs. In contrast, phenobarbital significantly elevated threshold and reduced seizure severity and afterdischarge duration. Amitriptyline was the most effective antidepressant, attenuating both seizure severity and afterdischarge duration.