Premium
A quantitation of myelin‐associated glycoprotein and myelin basic protein loss in different demyelinating disease
Author(s) -
Gendelman Howard E.,
Pezeshkpour Gholam H.,
Pressman Norman J.,
Wolinsky Jerry S.,
Quarles Richard H.,
Dobersen Michael J.,
Trapp Bruce D.,
Kitt Cheryl A.,
Aksamit Allen,
Johnson Richard T.
Publication year - 1985
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410180309
Subject(s) - myelin , demyelinating disease , myelin associated glycoprotein , glycoprotein , myelin basic protein , myelin sheath , medicine , disease , immunology , pathology , biology , central nervous system , biochemistry
The loss of myelin‐associated glycoprotein (MAG) and myelin basic protein (MBP) was compared by quantitative immunocytochemistry in demyelinating lesions of measles encephalomyelitis (ME), multiple sclerosis (MS), and progressive multifocal leukoencephalopathy (PML). Serial sections from paraffin‐embedded tissue were reacted with antisera for MAG and MBP, and areas of staining loss were compared morphometrically. Lesions in ME showed MAG loss equal to that of MBP, lesions of PML showed MAG loss greater than that of MBP, and MS lesions showed a mixture of patterns. These data demonstrate distinctive patterns of MAG and MBP loss in these three diseases.