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Metachromatic leukodystrophy manifesting as a schizophrenic disorder: Computed tomographic correlation
Author(s) -
Finelli Pasquale F.
Publication year - 1985
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410180117
Subject(s) - metachromatic leukodystrophy , leukodystrophy , arylsulfatase a , computed tomographic , medicine , cerebrotendinous xanthomatosis , pathology , radiology , computed tomography , disease , cholesterol
A 32‐year‐old woman with a 12‐year history of schizophrenia demonstrated symmetrical bifrontal and biparietal periventricular hypodensities on computed tomographic scan. Sural nerve biopsy and urine and leukocyte enzyme assay confirmed the diagnosis of metachromatic leukodystrophy. The computed tomographic correlate in an adult with metachromatic leukodystrophy in whom the psychiatric manifestations were the predominant clinical feature is described.