Premium
Basal ganglia glucose utilization after recent precentral ablation in the monkey
Author(s) -
Dauth George W.,
Gilman Sid,
Frey Kirk A,
Penney John B.
Publication year - 1985
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410170503
Subject(s) - globus pallidus , basal ganglia , putamen , subthalamic nucleus , caudate nucleus , substantia nigra , pallidotomy , neuroscience , internal capsule , cerebral cortex , indirect pathway of movement , biology , anatomy , medicine , central nervous system , dopamine , deep brain stimulation , parkinson's disease , white matter , disease , dopaminergic , radiology , magnetic resonance imaging
In the macaque monkey, unilateral ablation of areas 4 and 6 of Brodmann result initially in a signficant decrease of glucose metabolic activity in the ipsilateral caudate nucleus, putamen, globus pallidus, substantia nigra, and subthalamic nucleus. The contralateral hemisphere shows nonsignificant but consistently decreased activity in the caudate nucleus, putamen, and globus pallidus. Cerebral blood flow is decreased in the same pattern as the glucose metabolic activity. The change in glucose metabolic activity result from loss of neurons known to project directly from the cerebral cortex to the basal ganglia and also from indirect effect(diaschisis) in basal ganglia structures that do not receive connections from the cerebral cortex.