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Late‐onset Wilson's disease with neurological involvement in the absence of Kayser‐Fleischer rings
Author(s) -
Ross M. Elizabeth,
Jacobson Ira M.,
Dienstag Jules L.,
Martin Joseph B.
Publication year - 1985
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410170421
Subject(s) - fleischer , medicine , disease , wilson's disease , urinary system , pediatrics , pathology , german , archaeology , history
We report a patient with Wilson's disease whose case is unusual in two respects. First, the patient was 58 years of age when the diagnosis was made based on urinary, serum, and hepatic copper studies, as well as liver histological investigation. Second, despite the patient's neurological impairment, Kyser‐Fleischer rings had not developed. We conclude that in patients with chronic, degenerative neurological disease, particularly when associated with hepatic dysfunction, the diagnosis of Wilson's disease should be considered regardless of age at onset or the absence of Kyser‐Fleischer rings on slit lamp examination.