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Atypical presentation of progressive supranuclear palsy
Author(s) -
Davis P. H.,
Bergeron C.,
McLachlan D. R.
Publication year - 1985
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410170406
Subject(s) - progressive supranuclear palsy , apraxia , pseudobulbar palsy , parkinsonism , corticobasal degeneration , medicine , presentation (obstetrics) , ophthalmoparesis , dementia , frontotemporal dementia , psychology , physical medicine and rehabilitation , pediatrics , surgery , pathology , psychiatry , disease , aphasia , ptosis
Four pathologically documented cases of profressice supranuclear palsy are reported. Two patients exhinited severe dementia and 2 parkinsonism; none had the classic opthalmoplegia. On retrospective analysis, clues to the diagnosis included early prominent gait disturbance, apraxia of eyelid opening in 1 patient, lack of tremor, poor response to levodopa‐carbidopa, and severe rigidity with a posture of neck extension terminally in 1 patient. The clinical presentation of progressive supranuclear palsy, therefore, is not as stereotyped as previously thought, and the diagnosis can be overlooked if one adheres rigidly to the classic diagnostic criteria.