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Regional cerebral blood flow decreases during hyperglycemia
Author(s) -
Duckrow Robert B.,
Beard Daniel C.,
Brennan Robert W.
Publication year - 1985
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410170308
Subject(s) - cerebral blood flow , mannitol , medicine , ischemia , saline , endocrinology , plasma osmolality , blood flow , intraperitoneal injection , plasma glucose , anesthesia , insulin , chemistry , biochemistry , vasopressin
The presence of hyperglycemia before brain ischemia increases stroke‐related morbidity and mortality in experimantal animals and humans. However, little is known of the effect of hyperglycemia on regional cerebral blood flow (rCBF). Acute hyperglycemia was induced in awake but restrained rats by intraperitoneal injection of 50% D‐glucose. Regional flow was determined using [14C]iodoantipyrine and quantitative autoradiography. Elevation of plasma glucose from 11 to 39 mM was associated with a 24% reduction in rCBF when compared with controls that received normal saline. Intraperitoneal D‐mannitol produced an elevation of plasma osmolality equivalent to that observed with glucose. However, rCBF was only reduced by 10%. Hyperglycemia appears to produce a global decrease in rCBF in awake rats that cannot be completely explained by the attendant increase in plasma osmolality. If a similar influence is present during brain ischemia, hyperglycemia could extend areas of critical flow limitation.