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Tetrabenazine induces acute dystonic reactions
Author(s) -
Burke Robert E.,
Reches Avinoam,
Traub Michael M.,
Ilson Joyce,
Swash Michael,
Fahn Stanley
Publication year - 1985
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410170217
Subject(s) - tetrabenazine , dystonia , dopamine , blockade , medicine , dopamine receptor , pharmacology , neuroscience , dopamine receptor d2 , receptor , psychology
Abstract Four patients suffered acute dystonic reactions casued by tetrabenzine. Because dystonic reactions have previously been reported only after dopamine receptor blockade and not with dopamine deplection, it is likely that the ability of tetrabenazine to induce acute dystonia is due to its dopamine receptor blocking properties. Because tertrabenazine can induce acute dystonia even when combined with α‐methyl‐ p ‐tyrosine, presynaptic dopamine stores may not be necessary for these reactions to occur.