Premium
Intracranial pressure, conductance to cerebrospinal fluid outflow, and cerebral blood flow in patients with benign intracranial hypertension (pseudotumor cerebri)
Author(s) -
Gjerris F.,
Sørensen P. Soelberg,
Vorstrup S.,
Paulson O. B.
Publication year - 1985
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410170209
Subject(s) - pseudotumor cerebri , cerebrospinal fluid , intracranial pressure , cerebral blood flow , medicine , lumbar puncture , cerebral perfusion pressure , cerebrospinal fluid pressure , anesthesia , white matter , perfusion , blood pressure , blood flow , nuclear medicine , pathology , magnetic resonance imaging , radiology
Intracranial pressure, conductance to cerebrospinal fluid outflow, and cerebral blood flow were investigated in 14 patients with benign intracranial hypertension (pseudotumor cerebri). Intracranial pressure was increased in 9 patients (20 to 30 mm Hg), borderline in 4 patients (15 to 18 mm Hg), and normal in 1 patient (8 mm Hg). Six patients had plateau waves, and all had B waves in more than 50% of the monitored time. Conductance to cerebrospinal fluid outflow, measured by a lumbo‐lumbar perfusion method, was significantly reduced: 0.042 ml·mm Hg −1 ·min −1 (± 0.004 {SEM}; normal more than 0.080 ml·mm Hg −1 ·min −1 ). Cerebral blood flow was measured by xenon 133 inhalation and single photon emission computer tomography. Mean hemispheric flow was normal in all cases, averaging 59 ± 9 ml·100 gm −1 ·min −1 . Only 2 patients showed focal low‐flow areas. Thus, a disturbance of cerebrospinal fluid circulation seems to be of pathogenetic significance in benign intracranial hypertension.