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Computed tomographic analysis of brain morphometrics in 30 healthy men, aged 21 to 81 years
Author(s) -
Schwartz Michael,
Creasey Helen,
Grady Cheryl L.,
DeLeo James M.,
Frederickson Hal A.,
Cutler Neal R.,
Rapoport Stanley I.
Publication year - 1985
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410170208
Subject(s) - grey matter , white matter , atrophy , cerebrospinal fluid , lateral ventricles , medicine , morphometrics , thalamus , nuclear medicine , computed tomographic , brain size , anatomy , computed tomography , magnetic resonance imaging , pathology , radiology , biology , fishery
Computed transverse axial tomography (CT) was employed to examine brain morphometrics in 30 healthy men, aged 21 to 81 years. Seven consecutive CT slices 30 to 80 mm above the inferior orbitomeatal line were analyzed. CT numbers in grey and white matter regions were not correlated significantly with age (p<0.05), nor were right/left ratios for derived parameters. The volume of gray matter was correlated negatively with age (p>0.05), and the volume of cerebrospinal fluid correlated positively with age, in the seven slices. The volumes of the lateral and third ventricles were elevated in the elderly, and volumes of the thalamus and tenticular nucleus were reduced. The results demonstrate that brain atrophy, evidenced by a loss of grey matter and by dilatation of cerebrospinal fluid spaces, occurs in the healthy elderly, and provide baseline CT‐derived brain morphometric data for healthy men in relation to age.