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In vivo measurement of brain tumor pH using [ 11 C]DMO and positron emission tomography
Author(s) -
Rottenberg D. A.,
Ginos J. Z.,
Kearfott K. G.,
Junck L.,
Dhawan V.,
Jarden J. O.
Publication year - 1985
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410170116
Subject(s) - positron emission tomography , in vivo , white matter , nuclear medicine , brain tumor , chemistry , brain positron emission tomography , positron , positron emission , brain tissue , tomography , nuclear magnetic resonance , medicine , pathology , magnetic resonance imaging , preclinical imaging , radiology , physics , biomedical engineering , biology , nuclear physics , microbiology and biotechnology , electron
In vivo measurements of regional brain tissue/tumor pH ( r pH) have been accomplished in 9 patients with primary or metastatic brain tumors using[ 11 C]dimethyloxazolidinedione ([ 11 C]DMO) and positron emission tomography. Tumor r pH values ranged from 6.88 to 7.26, whereas gray matter and white matter r pH values ranged from 6.74 to 7.09 and from 6.77 to 7.03, respectively. Our result, which are consistent with reported [ 14 C]DMO autoradiographic measurements of brain and tumor pH, suggest that the pH microenvironment of brain tumors is not more “acidic” than that of normal gray or white matter.