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Ocular palsy preceding chronic relapsing polyneuropathy by several weeks
Author(s) -
Donaghy Michael,
Earl C. J.
Publication year - 1985
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410170112
Subject(s) - medicine , dysphagia , weakness , polyneuropathy , peripheral neuropathy , palsy , surgery , cerebrospinal fluid , anesthesia , pathology , diabetes mellitus , alternative medicine , endocrinology
Three patients exhibited an unusual variant of chronic relapsing polyneuritis in which extroacular muscle palsies developed 19 days, 20 days, and 3 1/2 months, respectively, before the neuropathy affected the limbs. The peripheral Neuropathy evolved over 7 to 12 weeks, lasted 15 months to 13 years, and relapsed in every case. Each patients had dysphagia, areflexia, sensory loss, and weakness of all four limbs, which in two was asymmetrical. Slowed motor nerve conduction and prolonged F wave latencies were present, and the cerebrospinal fluid protien level was elevated without increased cell count. No patient recovered fully despite treatment with immunosuppressant drugs.