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Idiopathic dystonia‐parkinsonism with marked diurnal flucuation of symptoms
Author(s) -
Sunohara Nobuhiko,
Mano Yukio,
Ando Kazuya,
Satoyoshi Eijiro
Publication year - 1985
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410170110
Subject(s) - parkinsonism , dystonia , trihexyphenidyl , bromocriptine , anesthesia , medicine , amantadine , homovanillic acid , movement disorders , hydrochloride , psychology , psychiatry , chemistry , pharmacology , disease , prolactin , hormone , receptor , organic chemistry , serotonin
Studies were performed on 5 patients with idiopathic dysotnia‐parkinsonism, each of whom had minor dystonic movements and parkinsonian symptoms with marked diurnal fluctuation. Levels of homovanillic acid and 5‐hydroxyindoleacetic acid were not defferent from those in controls. Considerable improvement in dystonic movements and parkinsonian symptoms was obtained with a small dose of L ‐dopa, trihexyphenidyl hydrochloride, amantadine, or bromocriptine hydrochloride. Electrophysiological investigation confirmed that the dystonic movements, which became remarkably worsened on attempted movement, contributed importantly to the diurnal fluctuation of symptoms.