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Roles of biogenic amines and cyclic nucleotides in seizure mechanisms
Author(s) -
Ferrendelli James A.
Publication year - 1984
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410160715
Subject(s) - dopamine , norepinephrine , serotonin , guanosine , nucleotide , adenosine , cyclic nucleotide , cyclic gmp , chemistry , cyclic adenosine monophosphate , cyclic guanosine monophosphate , neurotransmitter , medicine , endocrinology , biochemistry , enzyme , central nervous system , nitric oxide , receptor , gene
Data indicating that some biogenic amines (norepinephrine, dopamine, and serotonin), adenosine, and the cyclic nucleotides [adenosine 3′,5′‐monophosphate (cyclic AMP) and guanosine 3′,5′‐monophosphate (cyclic GMP)] are involved in pathophysiological mechanisms of seizures are reviewed. Currently available evidence leads to the conclusion that norepinephrine, serotonin, cyclic AMP, and perhaps dopamine are involved in processes that inhibit or confine seizure activity in brain and that cyclic GMP may be involved in mechanisms responsible for initiating or maintaining seizure activity.