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Neonatal Citrobacter meningitis: Pathogenesis of cerebral abscess formation
Author(s) -
Foreman Susan D.,
Smith Edward E.,
Ryan Nell J.,
Hogan Gwendolyn R.
Publication year - 1984
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410160606
Subject(s) - meningitis , abscess , brain abscess , medicine , vasculitis , pathological , white matter , infarction , pathogenesis , pathology , necrosis , liquefaction , cerebral infarction , radiology , surgery , magnetic resonance imaging , ischemia , geology , myocardial infarction , disease , geotechnical engineering
In 2 premature infants with brief survival, the major pathological feature of Citrobacter meningitis consisted of vasculitis and infarction with necrosis and liquefaction of large portions of the white matter of the hemispheres. Areas of decreased density demonstrated on computed tomographic head scan represented infarction with necrosis, liquefaction, and cavitation and not a classic abscess. This finding has clinical significance, because surgical drainage of liquefied infarcts is rarely indicated and could further damage the relatively preserved cortex.