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Phenytoin interacts with calcium channels in brain membrances
Author(s) -
Greenberg David A.,
Cooper Edward C.,
Carpenter Celia L.
Publication year - 1984
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410160514
Subject(s) - phenytoin , nitrendipine , carbamazepine , pharmacology , calcium channel , clonazepam , valproic acid , antagonist , phenobarbital , verapamil , chemistry , calcium , anticonvulsant , voltage dependent calcium channel , drug interaction , drug , medicine , epilepsy , biochemistry , receptor , psychiatry
Phenytoin at concentrations of between 30 and 300 μM inhibited binding of the calcium antagonist { 3 H} nitrendipine to voltage‐dependent calcium channels in brain membranes. Other anticonvulsants (phenobarbital, carbamazepine, valproic acid, and clonazepam) failed to inhibit binding or did so only at concentration much higher than occur clinically. Calcium channel blockade may be important in the clinical actions of phenytoin, including certain of the adverse effects of the drug.