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Hippocampal dendritic abnormalities in a rat model of phenylketonuria
Author(s) -
Lacey Daniel J.
Publication year - 1984
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410160508
Subject(s) - dendritic spine , hippocampal formation , hippocampus , neuroscience , golgi apparatus , hyperplasia , spine (molecular biology) , medicine , psychology , biology , pathology , bioinformatics , biochemistry , cell
An increased concentration of dendritic spines was present in one region of the hippocampus in rats made hyperphenylalaninemic (phenylketonuria model). It is uncertain whether this finding resulted from an actual hyperplasia or a failure of maturational spine reduction. The result is unusual in that Golgi studies of most mental retardation syndromes and relevant animal models have shown loss of dendritic spines.