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Cerebral amyloid angiopathy causing intracranial hemorrhage
Author(s) -
KalyanRaman Uma P.,
KalyanRaman Krishna
Publication year - 1984
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410160308
Subject(s) - cerebral amyloid angiopathy , medicine , amyloid (mycology) , dementia , angiopathy , pathology , intracerebral hemorrhage , stroke (engine) , brain hemorrhage , pathogenesis , senile plaques , subarachnoid hemorrhage , alzheimer's disease , radiology , surgery , disease , neurosurgery , mechanical engineering , engineering , diabetes mellitus , endocrinology
Abstract Ten cases of sporadic cerebral amyloid angiopathy (CAA) were seen as intracranial hemorrhage. CAA was seen as a stroke or catastrophic intracranial hemorrhage in all cases. CAA complicated by intracranial hemorrhage carried a high mortality; 9 of 10 patients died in spite of aggressive medical or surgical treatment. Senile dementia of Alzheimer's type was an associated finding in only 1 patient. Computed tomographic scanning in 4 patients initially was not diagnostic for hemorrhage. Lambda chains and amyloid P protein were demonstrated in the areas of amyloid angiopathy immunocytochemically. The pathogenesis of hemorrhage in CAA could be either increased fragility of amyloid‐laden blood vessels or rupture of microaneurysms. Surgical treatment of intracranial hemorrhage in CAA should therefore be undertaken with caution.