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Cholesterol and phospholipids in cultured skin fibroblasts from patients with dystonia
Author(s) -
Maltese William A.,
De Vivo Darryl C.
Publication year - 1984
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410160215
Subject(s) - phospholipid , dystonia , cholesterol , abnormality , medicine , endocrinology , biology , pathology , membrane , biochemistry , neuroscience , psychiatry
Abstract Cultured skin fibroblasts from patients with hereditary (recessive) torsion dystonia or adult‐onset sporadic dystonia and from healthy volunteers were compared with respect to total cellular cholesterol, total phospholipid, and phospholipid composition. Differences that could be attributed specifically to dystonia were not detected. The data suggest that the reported cell membrane abnormality in recessive torsion dystonia does not involve a generalized defect in cholesterol or phospholipid metabolism.