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The effect of normal aging on patterns of local cerebral glucose utilization
Author(s) -
Kuhl David E.,
Metter E. Jeffrey,
Riege Walter H.,
Hawkins Randall A.
Publication year - 1984
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410150726
Subject(s) - putamen , caudate nucleus , cerebral cortex , metabolic rate , temporal cortex , cortex (anatomy) , fluorodeoxyglucose , volunteer , medicine , nuclear medicine , positron emission tomography , psychology , neuroscience , biology , agronomy
When the fluorine‐18‐labeled fluorodeoxyglucose ( 18 FDG) scan was applied to 40 normal volunteer subjects aged 18 to 78 years, mean local cerebral metabolic rate for glucose (lCMRGlu) declined with advancing age at a faster rate than was reported for mean local cerebral metabolic rate for oxygen. Slopes of decline with age were similar in the centrum semiovale, caudate nucleus, putamen, and overall frontal, temporal, parietal, and occipital cortex. Superior frontal cortex and posterior inferior frontal cortex were exceptions, undergoing more rapid metabolic decline with age than in other parts of the brain. Measurements of the rate constants for transport and phosphorylation processes indicate that their change with aging had no major effect on the measurement of lCMRGlu by the 18 FDG method.