In vivo measurement of regional brain tissue pH using positron emission tomography | Zendy

Rottenberg D. A. | Zendy; Ginos J. Z. | Zendy; Kearfott K. J. | Zendy; Junck L. | Zendy; Bigner D. D. | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

In vivo measurement of regional brain tissue pH using positron emission tomography

Author(s) -

Rottenberg D. A.,

Ginos J. Z.,

Kearfott K. J.,

Junck L.,

Bigner D. D.

Publication year - 1984

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.410150718

Subject(s) - positron emission tomography , nuclear medicine , hematocrit , brain tissue , positron , in vivo , human brain , medicine , chemistry , biomedical engineering , physics , biology , microbiology and biotechnology , quantum mechanics , psychiatry , electron

Carbon‐11‐labeled dimethyloxazolidinedione ([ 11 C]DMO) was injected intravenously into human subjects, and serial positron emission tomographic (PET) scans were obtained until brain‐blood equilibration was achieved or could be accurately predicted from dynamic PET and 11 C blood data. Knowledge of regional brain‐blood partition coefficients for DMO, together with measurements of arterial blood hematocrit and pH, permitted the calculation of regional brain tissue and tumor pH (rpH). [ 11 C]DMO PET rpH values were similar to rpH values derived from quantitative autoradiographic measurements of [ 14 C]DMO concentrations in rat brain slices.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research