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In vivo measurement of regional brain tissue pH using positron emission tomography
Author(s) -
Rottenberg D. A.,
Ginos J. Z.,
Kearfott K. J.,
Junck L.,
Bigner D. D.
Publication year - 1984
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410150718
Subject(s) - positron emission tomography , nuclear medicine , hematocrit , brain tissue , positron , in vivo , human brain , medicine , chemistry , biomedical engineering , physics , biology , microbiology and biotechnology , quantum mechanics , psychiatry , electron
Carbon‐11‐labeled dimethyloxazolidinedione ([ 11 C]DMO) was injected intravenously into human subjects, and serial positron emission tomographic (PET) scans were obtained until brain‐blood equilibration was achieved or could be accurately predicted from dynamic PET and 11 C blood data. Knowledge of regional brain‐blood partition coefficients for DMO, together with measurements of arterial blood hematocrit and pH, permitted the calculation of regional brain tissue and tumor pH (rpH). [ 11 C]DMO PET rpH values were similar to rpH values derived from quantitative autoradiographic measurements of [ 14 C]DMO concentrations in rat brain slices.