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Assessment of dopamine receptor densities in the human brain with carbon‐11‐labeled N‐methylspiperone
Author(s) -
Wagner Henry N.,
Burns H. Donald,
Dannals Robert F.,
Wong Dean F.,
Langström Bengt,
Duelfer Timothy,
Frost J. James,
Ravert Hayden T.,
Links Jonathan M.,
Rosenbloom Shelley B.,
Lukas Scott E.,
Kramer Alfred V.,
Kuhar Michael J.
Publication year - 1984
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410150715
Subject(s) - receptor , dopamine , dopamine receptor , human brain , positron emission tomography , neuroscience , dopamine receptor d1 , dopamine receptor d2 , pathological , chemistry , biology , psychology , medicine
We describe the use of carbon‐11‐labeled 3‐N‐methylspiperone, a ligand that preferentially binds to dopamine receptors in vivo, to image the receptors by positron emission tomography scanning in baboons and, for the first time, in a human. The method has now been used in 58 humans for noninvasive assessment of the state of brain dopamine receptors under normal and pathological conditions.