Premium
Computed tomography in Alexander's disease
Author(s) -
Farrell Kevin,
Chuang Sylvester,
Becker Laurence E.
Publication year - 1984
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410150616
Subject(s) - white matter , computed tomography , medicine , disease , radiology , brain disease , pathology , magnetic resonance imaging
Computed tomography demonstrated contrast‐enhancing lesions in the periventricular frontal regions, caudate nuclei, and thalami in an infant with Alexander's disease. The distribution of the enhancing lesions corresponded to the areas in which Rosenthal fibers were most prominent. These radiological findings have not been described in other white matter diseases; thus, they may help to distinguish Alexander's disease from Canavan's disease and decrease the necessity for diagnostic brain biopsy.