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Mechanisms of recovery from aphasia: Evidence from serial xenon 133 cerebral blood flow studies
Author(s) -
Knopman David S.,
Rubens Alan B.,
Selnes Ola A.,
Klassen Arthur C.,
Meyer Maurice W.
Publication year - 1984
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410150604
Subject(s) - cerebral blood flow , aphasia , lateralization of brain function , diaschisis , medicine , cerebral infarction , blood flow , audiology , stroke (engine) , psychology , cardiology , anesthesia , neuroscience , ischemia , mechanical engineering , engineering , cerebellum
In 21 patients who suffered aphasia resulting from left hemisphere ischemic infarction, the xenon 133 inhalation cerebral blood flow techique was used to measure cerebral blood flow within 3 months and 5 to 12 months after stroke. In addition to baseline measurements, cerebral blood flow measurements were also carried out while the patients were performing purposeful listening. In patients with incomplete recovery of comprehension and left posterior temporal–inferior parietal lesions, greater cerebral blood flow occurred with listening in the right inferior frontal region in the late studies than in the early studies. In patients with nearly complete recovery of comprehension and without left posterior temporal–inferior parietal lesions, early listening studies showed diffuse right hemisphere increases in cerebral blood flow. Later listening studies in this latter patient group showed greater cerebral blood flow in the left posterior temporal–inferior parietal region. The study provides evidence for participation of the right hemisphere is language comprehension in recovering aphasics, and for later return of function in left hemisphere regions that may have been functionally impaired early during recovery.