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Parkinson's disease: Neuron loss in the nucleus basalis without concomitant Alzheimer's disease
Author(s) -
Nakano Imaharu,
Hirano Asao
Publication year - 1984
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410150503
Subject(s) - nucleus basalis , senile plaques , disease , degenerative disease , neuroscience , alzheimer's disease , cerebral cortex , parkinson's disease , medicine , pathology , neuron , psychology , cholinergic neuron , central nervous system
A representative region of the nucleus basalis of Meynert was investigated in 11 patients with idiopathic Parkinson's disease and compared with the identical region in 13 age‐matched control subjects. Simultaneously, the cerebral cortex and the nucleus basalis in the patients with Parkinson's disease were examined for senile plaques and Alzheimer's neurofibrillary tangles. The nucleus basalis was significantly depleted of its large neurons in Parkinson's disease ( p < 0.001 versus controls; Student t test), but in the majority of cases the neuron loss was not associated with Alzheimer's disease.