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Amyloid plaques in the brains of mice with Creutzfeldt–Jakob disease
Author(s) -
Tateishi Jun,
Nagara Hitoshi,
Hikita Kohtaro,
Sato Yuji
Publication year - 1984
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410150313
Subject(s) - kuru , scrapie , pathology , white matter , creutzfeldt jakob syndrome , senile plaques , disease , amyloid (mycology) , medicine , alzheimer's disease , biology , magnetic resonance imaging , prion protein , radiology
By intracerebral inoculation with the brain homogenates from 9 patients with Creutzfeldt‐Jakob disease, amyloid plaques were induced in mouse brains after incubation periods of 403 to 835 days. The plaques existed mainly in the cerebral white matter beneath the lateral ventricle walls amd were more numerous in the hemisphere where injection was made. Morpholoogical findings of the plaques were almost identical to those seen in patients wtih kuru and Creutzfeldt‐Jakob disease, and in animals with scrapie. They were also similiar to the cores of senile plaques seen in patients with alheimer's disease.