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Central nervous system catecholamine metabolism in Korsakoff's psychosis
Author(s) -
Martin Peter R.,
Weingartner Herbert,
Gordon Edna K.,
Burns R. Stanley,
Linnoila Markku,
Kopin Irwin J.,
Ebert Michael H.
Publication year - 1984
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410150212
Subject(s) - homovanillic acid , cerebrospinal fluid , psychosis , norepinephrine , catecholamine , metabolite , medicine , dopamine , endocrinology , serotonin , lumbar puncture , central nervous system , psychology , psychiatry , receptor
Abstract We attempted to replicate previous reports of impaired central noradrenergic activity in patients with Korsakoff's psychosis. No differences were demonstrated in lumbar cerebrospinal fluid concentrations of norepinephrine or its major metabolite, 3‐methoxy‐4‐hydroxypheny glycol (MHPG), or in the contribution of plasma to cerebrospinal fluid free MHPG in 6 patients with clinically well characterized Korsakoff's psychosis and 8 age‐matched healthy, normal volunteers. Likewise, cerebrospinal fluid concentrations of the major metabolites of dopamine (homovanillic acid) and serotonin (5‐hydroxyindoleacetic acid) were the same in patients and controls.