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Brain trace elements in Pick's disease
Author(s) -
Ehmann W. D.,
Alauddin M.,
Hossain T. I. M.,
Markesbery W. R.
Publication year - 1984
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410150119
Subject(s) - selenium , zinc , trace element , neutron activation analysis , manganese , chemistry , chlorine , pathogenesis , wet weight , rubidium , medicine , radiochemistry , endocrinology , pathology , potassium , organic chemistry
The trace element content of the brain of two patients with Pick's disease examined postmortem was studied using instrumental neutron activation analysis. Results showed significant increases in chlorine, iron, manganese, sodium, and phosphorus and significant decreases in chromium, cesium, rubidium, and selenium and in the mean freeze‐dried to wet‐weight ratio for patients with Pick's disease compared with control patients. Brain zinc content was not elevated in the two patients, a finding that fails to support the hypothesis that elevated zinc levels play a role in the pathogenesis of Pick's disease.