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Coma and thyrotoxicosis
Author(s) -
Newcomer John,
Haire William,
Hartman Charles R.
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410140615
Subject(s) - coma (optics) , corticospinal tract , plasmapheresis , medicine , triiodothyronine , disease , graves' disease , neurologic disease , pyramidal tracts , pediatrics , anesthesia , hormone , psychiatry , immunology , magnetic resonance imaging , radiology , physics , diffusion mri , antibody , optics
A patient with Graves' disease was in coma with evidence of corticospinal tract disease. Treatment with standard pharmacological measures and plasmapheresis resulted in the reduction of total thyroxine from 28.8 μg/ dl to 10.0 μg/dl and of triiodothyronine from 332 ng/dl to 150 ng/dl. These laboratory findings were associated with clinical stabilization, improvement of mental status, and resolution of the findings of corticospinal tract disease. These data support previous contentions relating reversible corticospinal tract disease to thyrotoxicosis.