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Immunoreactive myelin proteolipid protein—like activity in cerebrospinal fluid and serum of neurologically impaired patients
Author(s) -
Trotter John L.,
Wegescheide Cindy L.,
Garvey William F.
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410140510
Subject(s) - radioimmunoassay , myelin , cerebrospinal fluid , multiple sclerosis , proteolipid protein 1 , myelin proteolipid protein , central nervous system , medicine , myelin basic protein , pathology , immunology , chemistry
Two hundred seventy‐eight samples of cerebrospinal fluid and 273 samples of sera from a variety of neurological patients were examined by radioimmunoassay for myelin proteolipid protein–like reactivity as an index of structural damage to myelin. Groups of patients with active central nervous system damage could be distinguished easily, although there was a small percentage of false positive reactions. The reactivity was most marked in the demyelinative, encephalitic, and stroke categories. A radioimmunoassay for proteolipid protein of proper sensitivity and specificity may prove to be a useful objective clinical measure of the presence and degree of disease activity in multiple sclerosis and other diseases.