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Long‐term effects of treatment on endocrine function in children with brain tumors
Author(s) -
Duffner Patricia K.,
Cohen Michael E.,
Anderson Stephen W.,
Voorhess Mary L.,
MacGillivray Margaret H.,
Panahon Alvin,
Brecher Martin L.
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410140506
Subject(s) - medicine , endocrinology , luteinizing hormone , prolactin , endocrine system , hormone , testosterone (patch) , thyroid , urinary system , thyroid function , bone age , endocrine gland , follicle stimulating hormone
Fourteen children with brain tumors received endocrine evaluations at least one year following completion of cranial irradiation. Treatment consisted of operation (13 patients), craniospinal irradiation (6), whole brain irradiation (5), posterior fossa irradiation (3), and chemotherapy (10). Endocrine evaluation included bone age roentgenography and measurement of growth hormone (using sequential arginine and insulin stimulation), thyroxine, thyroid‐stimulating hormone, plasma cortisol, testosterone, prolactin, and urinary follicle‐stimulating hormone and luteinzing hormone. Ten of 12 children (83%) had abnormal responses to both tests of growth hormone stimulation. All growth hormonedeficient patients treated prior to puberty and tested at least 2 years following completion of cranial irradiation had decelerated linear growth. Results of thyroid function tests were abnormal in 4 patients: 2 patients had evidence of primary hypothyroidism, and 2 showed secondary or tertiary hypothyroidism. Two patients had inadequate cortisol responses to insulin hypoglycemia. Urinary follicle‐stimulating hormone and luteinizing hormone, serum prolactin, and serum testosterone levels were appropriate for age in all patients.