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{ 18 F}fluorodeoxyglucose positron emission tomography in refractory complex partial seizures
Author(s) -
Theodore William H.,
Newmark Michael E.,
Sato Susumu,
Brooks Rodney,
Patronas Nicholas,
de la Paz Robert,
Dichiro Giovanni,
Kessler Robert M.,
Margolin Richard,
Manning Ronald G.,
Channing Michael,
Porter Roger J.
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410140406
Subject(s) - positron emission tomography , temporal lobe , nuclear medicine , fluorodeoxyglucose , ictal , medicine , positron , positron emission , electroencephalography , complex partial seizures , radiology , epilepsy , physics , quantum mechanics , psychiatry , electron
Positron emission tomography with simultaneous electroencephalographic monitoring was performed with { 18 F}fluorodeoxyglucose in 20 patients with complex partial seizures who had normal computed tomographic scans. Seven patients had only unilateral epileptiform discharges on the electroencephalogram, 3 had predominantly unilateral discharges, and 10 had nonlocalized epileptiform abnormalities. Positron emission tomography showed a hypometabolic lesion in 16 of the 20 patients. Pathological changes in the hypometabolic region were found in postoperative specimens in 4 of 5 patients studied. Positron emission tomography was unaffected by the seizure frequency, state of alertness, or number of spike discharges during the scan. There was a tendency for patients to have higher overall metabolic rates when taking less medication. Seizures occurring during { 18 F}fluorodeoxyglucose uptake in 3 patients produced a hypermetabolic area at the interictal hypometabolic focus. Positron emission tomography sometimes showed more widespread hypometabolism than suspected on the basis of the scalp‐recorded electroencephalogram. The frontal lobe showed a greater degree of hypometabolism than the temporal lobe in 3 patients. Focal lesions may be identified by positron emission tomography even if the electroencephalographic abnormality is not well localized.