Premium
Congenic autoimmune murine models of central nervous system diseas in connective tissue disorders
Author(s) -
Alexander Elaine L,
Murphy Edwin D.,
Roths John B.,
E Garrett E.
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410140211
Subject(s) - congenic , connective tissue , central nervous system , pathology , medicine , connective tissue disease , neuroscience , biology , autoimmune disease , genetics , disease , gene
Congenic mice of the MRL/Mp strain spontaneously develop an autoimmune connective tissue disease that shares immunological and histopathological features with systemic lupus erythematosus, rheumatoid arthrithritis, and Sjögren's syndrome. The autoimmune disorder in these mice is accelerated markedly by the recessive gene lpr. By 6 month of age, MRL/Mp‐ lpr / lpr mice developed prominent mononuclear cell infiltrates restricted to the choriod plexus and meninges, whereas congeneric MRL/Mp‐+/+ mice (which lack the lpr gene) showed delayed but widespread inflammatory infiltrates involving cerebral vessels and meninges, with sparing of the choroid plexus. These distinctive patterns of cerebral inflammation, which are comparable in many respects to those seen in human connective tissue disease, provide some of the first animal models of relevant central nervous system histopathological processes associated with underlying connective tissue disease.