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Plasma concentrations of sodium valproate: Their clinical value
Author(s) -
Turnbull D. M.,
Rawlins M. D.,
Weightman D.,
Chadwick D. W.
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410140107
Subject(s) - epilepsy , plasma concentration , medicine , adverse effect , anticonvulsant , anesthesia , sodium , plasma levels , valproic acid , therapeutic index , gastroenterology , pharmacology , chemistry , drug , psychiatry , organic chemistry
Plasma valproate concentrations were monitored prospectively in 54 previously untreated adult patients with epilepsy. Dose and plasma concentration were highly correlated. Adverse effects were common in association with plasma levels above 100 μg/ml. In patients suffering tonic‐clonic seizures without focal symptoms, no seizures occurred when plasma levels were higher than 50 μg/ml. In patients with partial seizures, it was difficult to define a lower limit to a therapeutic range.