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Lithium interferes with reserpine‐induced dopamine depletion
Author(s) -
Reches Avinoam,
Hassan Mohamed N.,
Jackson Vernice,
Fahn Stanley
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410130617
Subject(s) - reserpine , tardive dyskinesia , lithium (medication) , dopamine , dyskinesia , tetrabenazine , pharmacology , medicine , endocrinology , schizophrenia (object oriented programming) , psychiatry , disease , parkinson's disease
Long‐term lithium treatment attenuated the hypokinetic effect of reserpine in a patient with tardive dyskinesia. In rats, prophylactic lithium administration inhibits reserpine‐induced dopamine depletion in the brain. These data indicate that lithium may limit the therapeutic efficacy of reserpine in tardive dyskinesia.