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Na + ‐ and K + ‐dependent adenosine triphosphatase changes in multiple sclerosis plaques
Author(s) -
Hirsch Hilde E.,
Parks Mary Ellen
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410130613
Subject(s) - adenosine triphosphatase , white matter , multiple sclerosis , atpase , pathophysiology , triphosphatase , adenosine , chemistry , enzyme , medicine , pathology , endocrinology , biochemistry , immunology , magnetic resonance imaging , radiology
Na + and K + ‐dependent adenosine triphosphatase [(Na + + K + )‐ATPase] was studied in microdissected samples from sections of histologically active and inactive plaques of multiple sclerosis. In active plaques the enzyme was found to be markedly reduced in activity, whereas in old, chronic plaques ATPase activities were higher than those of unaffected white matter. White matter from control patients and normal‐appearing white matter from MS patients did not differ with regard to ATPase activities. The results suggest that reversible changes in the sodium pump mechanism may be involved in the pathophysiology of multiple sclerosis.