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Familial paroxysmal dystonic choreoathetosis and response to alternate‐day oxazepam therapy
Author(s) -
Kurlan Roger,
Shoulson Ira
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410130415
Subject(s) - oxazepam , choreoathetosis , benzodiazepine , medicine , dosing , regimen , dystonia , anesthesia , pharmacology , psychiatry , receptor
Abstract A patient with familial paroxysmal dystonic choreoathetosis (FPDC) who was only transiently improved on daily benzodiazepine therapy showed sustained benefit from a regimen of alternate‐day oxazepam therapy. Our findings confirm that FPDC is responsive to benzodiazepine therapy and suggest that an alternate‐day dosing schedule, using a short‐acting benzodiazepine, may minimize receptor down regulation and thereby sustain the therapeutic effect.