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Seizures induced by carbachol, morphine, and leucine‐enkephalin: A comparison
Author(s) -
Snead O. Carter
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410130412
Subject(s) - carbachol , morphine , enkephalin , opiate , cholinergic , muscarinic acetylcholine receptor , endocrinology , chemistry , pharmacology , medicine , opioid , receptor
The electrical, behavioral, and pharmacological properties of seizures induced by morphine, leucine‐enkephalin, and the muscarinic cholinergic agonist carbachol were examined and compared. Low‐dose carbachol given intracerebroventricularly (ICV) produced seizures similar electrically to those produced by ICV morphine and leucineenkephalin, although there was some difference in site of subcortical origin of onset. Carbachol and morphine were similar in that they had the same anticonvulsant profile, produced similar behavioral changes, caused generalized absence seizures in low doses and generalized convulsive seizures in high doses, and were capable of chemical kindling. However, opiate‐induced seizures were not overcome by cholinergic antagonists, nor were carbachol seizures blocked by opiate antagonists. These data suggest that there may be a common noncholinergic, nonopiatergic system involved in mediating carbachol‐ and morphine‐induced seizures but not enkephalin seizures.