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Acute panautonomic neuropathy
Author(s) -
Low P. A.,
Dyck P. J.,
Lambert E. H.,
Brimijoin W. S.,
Trautmann J. C.,
Malagelada J. R.,
Fealey R. D.,
Barrett D. M.
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410130407
Subject(s) - medicine , lesion , biopsy , autonomic nerve , nerve biopsy , anesthesia , pathology , peripheral neuropathy , endocrinology , diabetes mellitus
Abstract Two patients with acute panautonomic neuropathy had severe impairment of sympathetic and parasympathetic function of acute onset. Autonomic tests suggesting a postganglionic lesion and direct evidence of loss of unmyelinated and small myelinated fibers on nerve biopsy were found in Patient 1. There was a selective loss of small myelinated and unmyelinated nerve fibers; C potential was absent in the in vitro compound action potential; dopamine‐β‐hydroxylase activity was unmeasurable. No definite abnormalities were found on the nerve biopsy of Patient 2. The acute panautonomic neuropathies appear to comprise a spectrum of somatic and autonomic involvement.