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Cerebellar cortex ultrastructure in ataxia‐telangiectasia
Author(s) -
PaulaBarbosa M. M.,
Ruela C.,
Tavares M. A.,
Pontes C.,
Saraiva A.,
Cruz C.
Publication year - 1983
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410130312
Subject(s) - cerebellar cortex , granular layer , ultrastructure , golgi apparatus , cerebellum , ataxia telangiectasia , cerebellar ataxia , purkinje cell , pathology , neuroscience , biology , cortex (anatomy) , ataxia , anatomy , medicine , endoplasmic reticulum , microbiology and biotechnology , dna , genetics , dna damage
An ultrastructural study of a biopsy fragment from the cerebellar cortex of a patient with ataxia‐telangiectasia was performed. There was a sharp reduction in the number of Purkinje cells and an increase in the number of Golgi epithelial cells. Despite the degeneration of Purkinje cell dendrites, the volumetric density of parallel fiber varicosities and the number of synapses in the molecular layer were only slightly reduced. No qualitative nor quantitative abnormalities were noted in the granular layer. An analysis is made of the severe changes in cerebellar circuitry of this patient and their probable functional implications.